It has been pointed out that the perpetual, site-wide license model is not well suited to everyone. For those who work at a startup, where the focus is sometimes on surviving for the next year, perpetual licenses hold little appeal. Further, for lone modelers, an unlimited-user license is also overkill. Those most penalized are the ones who realize they can do all their lead generation and optimization with pretty much only OpenEye software. So OpenEye offers an annual license package designed for small groups or companies that want to work from start to finish with OpenEye software.

We have also introduced an annual license, per research group, non-commercial software package for academics, non-profits and government organizations whose work has a high potential in becoming a commercial product or intellectual property offered for commercial licensing. This was not an option in the past and some of our customers have elected this route to support their specific situation. See more information about Annual, Per-research group, Non-commercial Software Package.

The annual software packages include: BROOD, EON, FILTER, FRED, OMEGA, QUACPAC, ROCS, SZYBKI, OEChem TK, VIDA & VIVANT. BROOD is an extremely fast application for bioisostere prediction. FILTER cleans the junk molecules from out from a virtual ligand library. QUACPAC enumerates all the appropriate protonation and tautomer states and puts good charges on them. OMEGA does the necessary 3D conformer generation. ROCS and EON do ligand-based screening for shape and electrostatics. If there is protein-structure information, FRED does the docking. SZYBKI refines the structure of the best leads. VIDA browses all the results and creates visual content that VIVANT "publishes" in PowerPoint^® or web pages. Along the way, OEChem TK helps with all the miscellaneous tasks.