We are continuing our 2025 miniWEBINAR series with our November session led by Chris Neale, Ph.D., who leads the molecular binding affinity solution group at OpenEye, Cadence Molecular Sciences. His expertise and interests include method development for structure-based drug design, cellular signal transduction, and uncertainty quantification. Chris is also an editorial board member at the Biophysical Journal.
About this session:
OpenEye’s Free Energy Nonequilibrium Switching (FE-NES) technology offers a powerful and scalable solution for binding affinity calculation during lead optimization. FE-NES consistently outperforms rapid scoring methods and rivals other advanced predictive tools in accuracy, enabling confident decision-making earlier in the drug discovery process. With elastic cloud scaling on the Orion® platform, FE-NES can rank hundreds of analogs in hours and expand to thousands using machine learning augmentation—dramatically accelerating timelines while maintaining scientific rigor. This combination of accuracy, speed, and scalability positions FE-NES as a critical tool that helps reduce downstream risk, optimize resource allocation, and drive more successful outcomes in your small molecule development programs.