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Calculate permeability coefficient and gain valuable kinetic insight into mechanism of passive membrane permeability, in a fraction of time when compared to other simulation techniques.
The new permeability workflow in the Orion® Small Molecule Discovery Suite helps researchers gain insight into small-molecule drug candidates’ potential chemical absorption and distribution profiles by predicting the speed and manner through which they cross membranes.
The Orion Permeability Floe (guided workflow) can be used early in the drug development process because it leverages a highly parallelizable path-sampling technique to assess permeability at scale. It does not require late-stage molecular synthesis like costly experimental methods, nor does it require prior knowledge of the membrane pathway like thermodynamics-based computational methods.