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The Orion®
Small Molecule Discovery Suite

Ligand- and Structure-Based Modeling

Rooted in science, optimized for performance. The Small Molecule Discovery Suite in Orion provides a complete range of easy-to-use ligand-based and structure-based modeling workflows for all your therapeutic project needs.

Increase the hit rate of your virtual screen, optimize affinity of your lead candidates, predict off-target effects early in discovery, and much more.

All functionality is accessible from the convenience of your web browser. You can build models, calculate, and analyze your results, as well as share, visualize, and discuss data with your colleagues in real-time. Collaboration has never been easier.

Small Molecule Discovery in Orion

OpenEye continues to provide state-of-the-art science, massive throughput, and the scalability required to meet your most challenging drug discovery projects.

With the Orion Small Molecule Discovery Suite, you get:

  • Robust science in easy-to-use workflows. Leverage trusted OpenEye science from ready-to-use Orion workflows (Floes)
  • Convenience. Access drug discovery modeling workflows for data preparation, modeling, and analysis from a unified web environment
  • Sketch and search. Easily perform 2D and 3D search of more than 5 billion commercially available compounds, making your large-scale virtual screening faster and easier
  • Time and cost savings. Save time and money with workflows that are optimized for speed, cloud performance, and cost efficiency
  • No restrictions. Tackle your most challenging therapeutic projects without licensing restrictions on the number of modeling tasks you perform or the size of your calculations


Watch the on-demand webinar on the Overview of Orion Small Molecule Discovery Suite

Workflows for All Stages of Drug Discovery

The Orion Small Molecule Discovery Suite provides easy-to-use automated Floes (guided workflows) for all stages of drug discovery.



Cheminformatics, Data Preparation, and Analysis

Quantum Calculations

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