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Orion® Formulations Suite
Find Promising Formulation Candidates with Crystal Structure Prediction
The Orion® Formulations Suite* includes robust crystal structure prediction (CSP) workflows and intrinsic solubility calculations that lets researchers uncover promising candidates for formulation early in the drug development process. With the Orion CSP methodology, researchers get:
- Robust science in easy-to-use workflows. Walk through a series of steps that use crystal-specific force fields and Quantum Mechanics (QM)-energy models. Eliminate high-energy packings that are more likely to be unstable and identify tightly packed, low-energy crystal structures that are more likely to be stable and suitable candidates for formulation.
- Fewer late-stage hurdles. Reduce the likelihood of discovering polymorphs during later stages of development, or even after approval, thereby minimizing the chances of unexpected safety concerns, drug recalls, and financial losses. The computational CSP method in Orion lets researchers explore the polymorph landscape more thoroughly than possible with time-consuming and costly experimental methods.
- Fast and accurate results, even with large datasets. Break free from hardware and compute-time constraints by leveraging the massive scaling made possible when running Orion on Amazon Web Services (AWS). From geometry optimization to entropy calculation, Orion employs novel parallelization methods that return results quickly and accurately, even for large datasets. What used to take days now takes only hours.
Download White Paper: How to Speed Up Your Drug Development with Crystal Structure Prediction