![](https://www.eyesopen.com/hubfs/mjtw-assets/backgrounds/molecule-bg-accent.png)
Applications
OpenEye’s downloadable on-premise (desktop and server) applications provide you the tools to help you design potent and selective bioactive molecules. Combining scientific innovations with the best software engineering principles, our on-premise applications are well known for both efficiency and robustness.
![on premise apps image Sept 2023-2](https://www.eyesopen.com/hs-fs/hubfs/on%20premise%20apps%20image%20Sept%202023-2.png?width=2250&height=2250&name=on%20premise%20apps%20image%20Sept%202023-2.png)
Trusted Science.
AFITT
Automatic ligand fitting to crystallographic density
BROOD
Fragment replacement for molecular design
EON
Electrostatic similarity for lead-hopping
FILTER
Compound property calculation & removal of undesirables
OEDocking
Docking for lead discovery and lead optimization
OMEGA
Rapid, accurate conformer generation
pKa Prospector
Providing protonation insights for novel molecules
QUACPAC
Tautomer/protomer enumeration & charge assignment
ROCS®
Shape similarity for lead discovery and lead hopping
SPRUCE
Protein preparation and modeling
SZMAP/GamePlan
Understanding water interactions in a binding site
SZYBKI/FreeForm
Molecular energetics with force fields
VIDA
Visualization & communication of modeling results
SiteHopper
Protein binding sites similarity search
![](https://play.vidyard.com/CfpVg4nEp6mGnGzVbHzgYb.jpg)
Delivered the Way You Need.
RESOURCES