
Trusted Science. Delivered the Way You Need.
Ligand-Based Design
Identify and refine promising candidates with powerful ligand-based shape and electrostatic methods that researchers have trusted for more than 20 years. OpenEye delivers easy-to-use tools with remarkable speed.

Trusted Science.
2D Ligand-Based Methods
- Property Calculation and Filter (FILTER)
- Estimate pKa Value and Protonation (pKa Prospector)
- Tautomer / Protomer Enumeration & Charge Assignment (QUAPAC)
3D Ligand-Based Methods
- Rapid and Accurate Conformer Generation (OMEGA)
- Shape and Chemical Features Similarity Search (ROCS®, FastROCS™, FastROCS Plus)
- Fragment Replacement for Molecular Design (BROOD)
- Electrostatic Similarity for Lead-hopping (EON)
- 3D Quantitative Structure–Activity Relationship (3D-QSAR)


Delivered the Way You Need.
miniWebinar: Opening up the druggable universe one cryptic pocket at a time
miniCUP San Francisco 2025
miniCUP San Diego 2025
miniWebinar: Faster, Larger, Smarter: Filling the Funnel for Ultra-Large Scale Virtual Screening
miniCUP Boston 2025
miniCUP San Francisco 2025
miniCUP San Diego 2025
miniWebinar: Faster, Larger, Smarter: Filling the Funnel for Ultra-Large Scale Virtual Screening
miniCUP Boston 2025
Resources
Glimpse the Future through News, Events, Webinars and more
Webinar
miniWebinar: Opening up the druggable universe one cryptic pocket at a time
In our first miniWEBINAR of 2025 we were talking about a computational workflow to validate difficult-to-drug protein targets in "Opening up the druggable universe one cryptic pocket at a time" session presented by David LeBard, Head of Enhanced Sampling at OpenEye, Cadence Molecular Sciences,
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Event
miniCUP San Francisco 2025
miniCUP San Francisco 2025 will be held on October 7th, 2025 OpenEye's miniCUP series brings our latest scientific advancements to you. Our upcoming miniCUP San Francisco is a single-day in-person gathering that will provide the opportunity to hear presentations from OpenEye and industry speakers, as well as to learn about the recent updates to the Orion® molecular design platform and our applications and toolkits. Come for the science, and stay for robust discussion at a cocktail reception following the event.
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