![](https://www.eyesopen.com/hubfs/mjtw-assets/backgrounds/molecule-bg-accent.png)
Trusted Science. Delivered the Way You Need.
Ligand-Based Design
Identify and refine promising candidates with powerful ligand-based shape and electrostatic methods that researchers have trusted for more than 20 years. OpenEye delivers easy-to-use tools with remarkable speed.
![Ligand-based design.](https://www.eyesopen.com/hs-fs/hubfs/ligand-based-design1.png?width=663&height=530&name=ligand-based-design1.png)
Trusted Science.
2D Ligand-Based Methods
- Property Calculation and Filter (FILTER)
- Estimate pKa Value and Protonation (pKa Prospector)
- Tautomer / Protomer Enumeration & Charge Assignment (QUAPAC)
3D Ligand-Based Methods
- Rapid and Accurate Conformer Generation (OMEGA)
- Shape and Chemical Features Similarity Search (ROCS®, FastROCS™, FastROCS Plus)
- Fragment Replacement for Molecular Design (BROOD)
- Electrostatic Similarity for Lead-hopping (EON)
![Ligand-based design.](https://www.eyesopen.com/hs-fs/hubfs/ligand-based-design2.png?width=700&height=449&name=ligand-based-design2.png)
![Ligand-based design.](https://www.eyesopen.com/hs-fs/hubfs/ligand-based-design4.png?width=700&height=334&name=ligand-based-design4.png)
Delivered the Way You Need.
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