Since the input molecules must already be aligned, EON is suitable for analyzing the output structures from programs such as ROCS, thus yielding compounds with similar shape and electrostatics.
EON contributes significantly to lead generation and library design. In a recent study, Abbott scientists reported that EON's post-processing of ROCS hits helped them lead-hop a MCH-1 series that had demonstrated in vivo potency issues . In a chemical genomics project directed toward antagonists for NAADP, EON was used in complement to ROCS to identify a low nanomolar binder to the NAADP receptor .
For more detailed information on EON, check out the link below: