CONFORMER ENSEMBLES CONTAINING BIOACTIVE CONFORMATIONS
OMEGA is designed to sample accurately the conformational space of a wide variety of molecules. It generates multi-conformer databases with high speed and reliability, using two different algorithms, one for broadly drug-like molecules and one for highly flexible linear or macrocyclic molecules.
OMEGA samples the conformational space of drug-like molecules at speeds of hundreds of thousands of compounds per day on a CPU, and over a million molecules per day on a GPU.
OMEGA is very effective at reproducing bioactive conformations [1,2], and provides an optimal balance between speed and performance when used on large compound databases .
OMEGA conformational databases can be used as input to a variety of applications including docking engines (FRED), shape comparison tools (ROCS®) and pharmacophore perception algorithms.
OMEGA produces high-quality ensembles of conformations, with higher accuracy than those from many other methods . It has also been found to be the fastest of all commercially available conformer generators for drug-like molecules  and one of the fastest for macrocycles . For more detailed information on OMEGA, check out the link below: