OMEGA
OMEGA is the most widely used, most highly cited conformation generation tool available. It robustly samples conformational space at high speed, using two different algorithms, one for broadly drug-like molecules and one for macrocyclic or highly flexible linear molecules.
OMEGA is very effective at reproducing bioactive conformations [1,2], and provides an optimal balance between speed and performance when used on large compound databases [3].
OMEGA conformational databases can be used as input to a variety of applications including docking engines (FRED), shape comparison tools (ROCS®), ligand posing (POSIT), and pharmacophore perception algorithms.
When compared to other tools OMEGA demonstrates both higher accuracy [4] and higher speed [5,6]. For more detailed information on OMEGA, check out the link below:
Documentation
