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Webinar: UMI-based Error Correction in Antibody Sequence Analysis with AbXtract™ to Preserve the Full Diversity of Campaign Leads

Webinar: UMI-based Error Correction in Antibody Sequence Analysis with AbXtract™ to Preserve the Full Diversity of Campaign Leads

Join us for the miniWebinar "UMI-based Error Correction in Antibody Sequence Analysis with AbXtract™ to Preserve the Full Diversity of Campaign Leads" presented by Laura Spector, PhD, Scientist at Specifica, Inc., on Thursday, October 20, 2022, at 10 a.m. U.S. Eastern Daylight Time (EDT).

OpenEye, Cadence Molecular Sciences miniWebinars

OpenEye miniWebinars are designed to deliver compact information on the latest science and discovery from OpenEye. Your time is valuable. OpenEye’s miniWebinar format maximizes your learning from the experts in only 30 minutes. 

Please register for this miniWebinar here, which is hosted through GoToWebinar.

Webinar Summary 

Next-generation sequencing (NGS) provides a more complete overview of an antibody populations from in-vitro selections, but two factors affect recovery of the full diversity of antibody sequences.

First, the accumulation of polymerase chain reaction (PCR) and sequencing errors contributes noise to a selection output where strongly skewed clonal frequency distributions make it challenging to distinguish true sequences by read counts alone.

Second, in applications where minimal sequence differences may affect developability properties, discriminating between distinct sequences without over-correcting for putative PCR or sequencing errors is crucial.

In this webinar, we describe how AbXtract™ in OpenEye’s Orion® Antibody Discovery Suite uses information encoded in NGS Unique Molecular Identifiers (UMIs) to simultaneously mask noise and preserve the full diversity of a selection output.  


Please register for this miniWebinar here, which is hosted through GoToWebinar.

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Webinar Agenda

The presentation details are: 

  • Advantages and applications of UMIs in immunosequencing
  • Special design considerations for NGS with UMIs and automated floes
  • Building highly accurate consensus sequences from UMI-tagged reads with tunable frequency thresholds
  • Demonstrating the use of automated floes to identify and rank leads from antibody discovery campaigns using UMI-tagged NGS reads

Please register for this miniWebinar here, which is hosted through GoToWebinar.

This event takes place from 10 - 10:30 a.m. EDT translated into your timezone below:

  • 4 – 4:30 p.m. | Central European Summer Time (CEST)
  • 3 – 3:30 p.m. | British Summer Time (BST)
  • 10 – 10:30 a.m. | U.S. Eastern Daylight Time (EDT)
  • 9 – 9:30 a.m. | U.S. Central Daylight Time (CDT)
  • 8 – 8:30 a.m. | U.S. Mountain Daylight Time (MDT)
  • 7 – 7:30 a.m. | U.S. Pacific Daylight Time (PDT)

Please register here for the webinar, which will be hosted through GoToWebinar.

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