The produced output of SPRUCE is an OEDesignUnit. The OEDesignUnit has everything well componentized, making it easy to select which key pieces to include in the subsequent modeling tasks, and which to discard (e.g. excipients).
SPRUCE furthermore leverages the Iridium categorization  by providing the user with information about which structure is best to use for modeling. Additionally, SPRUCE highlights the parts of a structure that need special attention, if it is to be used in modeling.
SPRUCE provides an expanding array of modeling tasks, like point-mutations, side-chain re-modeling and loop modeling using a template-based approach.
SPRUCE, furthermore, provides access to several superposition methods, based on sequence, secondary structures, or active site shape, each providing benefits depending on the similarity of the proteins being superposed.
Structure-based drug design requires careful preparation of experimental structures for downstream modeling applications. SPRUCE is a comprehensive, biomodeling preparation tool that reads experimentally solved (or modeled) protein and/or nucleic acid structures in several file formats and makes them modeling ready, for docking or molecule simulations.
To find out how SPRUCE can help with your protein modeling projects, contact us at email@example.com